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| Name | Class |
|---|---|
| Indiana University | OTHER |
| Merck Sharp & Dohme LLC | INDUSTRY |
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To evaluate whether add-on to prostaglandin therapy with twice a day (bid) dorzolamide is statistically superior to twice a day (bid) timolol with regard to increasing ocular blood flow
Hypotensive treatments for glaucomatous optic neuropathy (GON), depending on their chemical composition can influence the ocular circulation independent of intraocular pressure (IOP) reduction. It is therefore important not only to identify ocular blood flow deficits in GON, but also document the influence of GON treatments on the ocular circulation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| combination topical glaucoma treatment | timolol or dorzolamide add on latanoprost monotherapy |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Color Doppler Imaging | Device | Color Doppler imaging (CDI) system for measurements of blood flow in the ophthalmic (OA), central retinal (CRA), and nasal (NPCA) and temporal (TPCA) posterior ciliary arteries. In each vessel, peak systolic velocity (PSV) and end diastolic velocity (EDV) were determined, and Pourcelot's resistive index will be calculated (RI = (PSV-EDV)/PSV). |
| Measure | Description | Time Frame |
|---|---|---|
| Ocular Color Doppler Imaging | Color Doppler Imaging
| 8 AM; 8 PM |
| Measure | Description | Time Frame |
|---|---|---|
| IOP, BP, OPP (mean, fluctuations, amplitude) | IOP, BP, OPP (mean, fluctuations, amplitude) Goldmann applanation tonometry Brachial artery pressure and radial pulse | 8 AM-12AM-4PM-8PM |
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Inclusion Criteria:
Exclusion Criteria:
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Regular visitors of Eye Clinic of Lithuania University of Health Science hospital
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| Name | Affiliation | Role |
|---|---|---|
| Ingrida Januleviciene, MD | Lithuania University of Health Science | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eye Clinic Lithuania Health Science Hospital Kaunas Clinics | Kaunas | 50009 | Lithuania |
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| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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No biospecimens will be retained
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