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| Name | Class |
|---|---|
| University Hospital, Grenoble | OTHER |
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The purpose of this study is to evaluate the impact of thromboembolic diseases and heparin complications in patients with a lower limb trauma supported by physicians of mountain.
The "M2M-thrombose" study is a prospective epidemiological multicenter study involving patients with a lower limb trauma in winter sport resorts. The following initial data required are type of immobilization, treatment with LMWH (Low Molecular Weight Heparin), type of injury (serious or not) and the rolling of the step (normal or abnormal) or no weight bearing.
A 3 month follow-up by phone will be realized by the Investigation Clinical Center in Grenoble. Data about risk factors of thromboembolic diseases, anticoagulant therapy, medical history, new event since inclusion (hospitalization, surgery, lower limb trauma or thromboembolic events) will be collected.
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| Measure | Description | Time Frame |
|---|---|---|
| impact of a thromboembolic disease and heparin's complications | Evaluation of the impact of a thromboembolic disease and heparin's complications in outpatients with a lower limb trauma are supported by physicians in winter sports resort. The patients will be contacted by phone 3 months after trauma to collect these data. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| compliance with the algorithm for prescribing heparin and consequences on the primary endpoint | The primary endpoint consists to check the impact of thromboembolic disease and adverse effects of anticoagulant therapy at 3 month. We compare the link between these consequences and the compliance with the algorithm about the indication of LMWH therapy. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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outpatients with a lower limb trauma, in winter sports resorts
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| Name | Affiliation | Role |
|---|---|---|
| Dominique LAMY, MD | Médecins de Montagne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| medical center "Le chevreuil" | Autrans | 38880 | France | |||
| Medical center "le pas du lac" |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10728025 | Background | Motykie GD, Zebala LP, Caprini JA, Lee CE, Arcelus JI, Reyna JJ, Cohen EB. A guide to venous thromboembolism risk factor assessment. J Thromb Thrombolysis. 2000 Apr;9(3):253-62. doi: 10.1023/a:1018770712660. No abstract available. | |
| 11715837 | Background | Edelsberg J, Ollendorf D, Oster G. Venous thromboembolism following major orthopedic surgery: review of epidemiology and economics. Am J Health Syst Pharm. 2001 Nov 1;58 Suppl 2:S4-13. doi: 10.1093/ajhp/58.suppl_2.S4. |
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| incidence of thromboembolic diseases and heparin complications in different subgroups | Analysis of subgroups depending on the trauma type, the type of immobilization or not, risk factors of thromboembolic diseases, rolling step and weight bearing. | 3 months |
| Description of the included patients | epidemiological description of included patients (age, sex, travel time...) | evaluation during inclusion visit |
| Epidemiological characteristics of patients with a thromboembolic event or an adverse effect of the treatment | 3 months |
| Avoriaz |
| 74110 |
| France |
| Medical center "les Soldanelles" | Bellevaux | 74470 | France |
| Medical center "le serre d'aigle" | Chantemerle | 05330 | France |
| Medical center of Combloux | Combloux | 74920 | France |
| Medical home | Flaine | 74300 | France |
| Medical center of flumet | Flumet | 73590 | France |
| Medical Center Brousse | Font-Romeu-Odeillo-Via | 66120 | France |
| Medical center of Beauregard - "les cyclamens" | La Clusaz | 74220 | France |
| Medical group "le Yéti" | La Clusaz | 74220 | France |
| Medical center | Lanslevillard | 73480 | France |
| Medical group "SELARL Sports médecine montagne" | Le Grand-Bornand | 74450 | France |
| Medical group of Peric | Les Angles | 66210 | France |
| Medical center of "Aiguille rouge" | Les Arcs | 73700 | France |
| Medical center "Val Montjoie" | Les Contamines-Montjoie | 74170 | France |
| SCP medical "le Bennevy" | Les Gets | 74260 | France |
| Medical center | Les Orres | 05200 | France |
| Medical center | Lullin | 74470 | France |
| Medical center of Jaillet | Megève | 74120 | France |
| Medical center of Peisey-Vallandry | Peisey Vallandry | 73210 | France |
| Resort of Peyragudes | Peyragudes | 65240 | France |
| Medical center "le rocher de l'aigle" | Saint-François-Longchamp | 73130 | France |
| Medical center "Fleur des alpes" | Saint-Gervais-les-Bains | 74170 | France |
| Medical center | Samoëns | 74340 | France |
| Medical center "medival" | Val-d'Isère | 73150 | France |
| Medical center of Valberg | Valberg Guillaumes | 06470 | France |
| Medical center | Vallouise | 05290 | France |
| Medical center | Villard-de-Lans | 38250 | France |
| 20456358 | Background | Lijfering WM, Rosendaal FR, Cannegieter SC. Risk factors for venous thrombosis - current understanding from an epidemiological point of view. Br J Haematol. 2010 Jun;149(6):824-33. doi: 10.1111/j.1365-2141.2010.08206.x. Epub 2010 Apr 29. |
| 9156412 | Background | Gensini GF, Prisco D, Falciani M, Comeglio M, Colella A. Identification of candidates for prevention of venous thromboembolism. Semin Thromb Hemost. 1997;23(1):55-67. doi: 10.1055/s-2007-996071. |
| 8544587 | Background | Eschwege V, Robert A. Strikes in French public transport and resistance to activated protein C. Lancet. 1996 Jan 20;347(8995):206. doi: 10.1016/s0140-6736(96)90393-1. No abstract available. |
| 12710842 | Background | Vaitkus PT, Leizorovicz A, Goldhaber SZ; PREVENT Investigator Group. Rationale and design of a clinical trial of a low-molecular-weight heparin in preventing clinically important venous thromboembolism in medical patients: the prospective evaluation of dalteparin efficacy for prevention of venous thromboembolism in immobilized patients trial (the PREVENT study). Vasc Med. 2002;7(4):269-73. doi: 10.1191/1358863x02vm449oa. |
| 16439370 | Background | Cohen AT, Davidson BL, Gallus AS, Lassen MR, Prins MH, Tomkowski W, Turpie AG, Egberts JF, Lensing AW; ARTEMIS Investigators. Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial. BMJ. 2006 Feb 11;332(7537):325-9. doi: 10.1136/bmj.38733.466748.7C. Epub 2006 Jan 26. |
| 8388353 | Background | Kujath P, Spannagel U, Habscheid W. Incidence and prophylaxis of deep venous thrombosis in outpatients with injury of the lower limb. Haemostasis. 1993 Mar;23 Suppl 1:20-6. doi: 10.1159/000216905. |
| 12091045 | Background | Jorgensen PS, Warming T, Hansen K, Paltved C, Vibeke Berg H, Jensen R, Kirchhoff-Jensen R, Kjaer L, Kerbouche N, Leth-Espensen P, Narvestad E, Rasmussen SW, Sloth C, Torholm C, Wille-Jorgensen P. Low molecular weight heparin (Innohep) as thromboprophylaxis in outpatients with a plaster cast: a venografic controlled study. Thromb Res. 2002 Mar 15;105(6):477-80. doi: 10.1016/s0049-3848(02)00059-2. |
| 12213943 | Background | Lassen MR, Borris LC, Nakov RL. Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization. N Engl J Med. 2002 Sep 5;347(10):726-30. doi: 10.1056/NEJMoa011327. |
| 17543652 | Background | Riou B, Rothmann C, Lecoules N, Bouvat E, Bosson JL, Ravaud P, Samama CM, Hamadouche M. Incidence and risk factors for venous thromboembolism in patients with nonsurgical isolated lower limb injuries. Am J Emerg Med. 2007 Jun;25(5):502-8. doi: 10.1016/j.ajem.2006.09.012. |
| ID | Term |
|---|---|
| D007869 | Leg Injuries |
| D013923 | Thromboembolism |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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