This is an open-label, multicenter, Phase Ib dose-escalation study to assess the safety, tolerability, and pharmacokinetics of GDC-0980 administered with either paclitaxel and carboplatin (with or without bevacizumab) or pemetrexed and cisplatin to patients with locally advanced or metastatic solid tumors.

Inclusion Criteria:

• Histologically or cytologically documented, incurable, locally advanced, or metastatic solid malignancy
• Adequate hematologic and end organ function
• For female patients of childbearing potential and male patients with partners of childbearing potential, agreement to use an effective form of contraception and to continue its use for the duration of the study
• Measurable disease per RECIST (Response Evaluable Criteria in Solid Tumors), with the exception of prostate cancer (two rising PSA Levels that meet the criteria of progression per PSA Working Group) and ovarian cancer (two rising CA-125 levels greater than the ULN)

Exclusion Criteria:

• Current dyspnea at rest due to complications of advanced malignancy, or other conditions requiring continuous supplemental oxygen
• Uncontrolled hypomagnesemia or hypokalemia
• History of Grade >= 3 fasting hyperglycemia
• Any condition requiring full-dose anticoagulants
• Known HIV infection
• Known untreated or active central nervous system (CNS) metastases
• Pregnancy, lactation, or breastfeeding
• Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to the first dose of study treatment or anticipation of need for major surgical procedure during the course of the study
• For Arm B: Conditions that preclude the use of bevacizumab
• For Arm C: Conditions that preclude the use of pemetrexed or cisplatin