Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)
Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)
The purpose of this study is to determine the acute efficacy of intrathecal clonidine to reduce blood pressure in hypertensive subjects with poor blood pressure control and describe its effects on cardiovascular function.
Hypertension occurs commonly, is associated with major morbidity and mortality, and responds poorly to current therapies in a small minority of compliant patients. The goal of this investigator-initiated study is to determine whether intrathecal administration of clonidine reduces blood pressure in hypertensive patients, focusing on a group who often achieve inadequate blood pressure control with multiple drug therapy.
After consent, pts will be screened and if qualified brought into center and intrathecal injection of clonidine given. Patients will be closely monitored for 4 hours, while data is collected.
Inclusion Criteria:
Exclusion Criteria:
Allergy to clonidine
Presently on clonidine orally or transdermally
Known or suspected correctable causes of secondary hypertension
Breast Feeding or Pregnant women
Unstable Ischemic Heart Disease
Unstable Angina
Intracoronary Stent Placement
Coronary bypass within last 6 months
Myocardial Infarction within last 6 months
Congestive Failure
Cardiac Arrhythmias
Known Cerebral Vascular Disease
Renal Disease
Evidence of Injection Site Infection
Known Bleeding Disorders
Hepatic Insufficiency
Renal Insufficiency
Participation in an investigational drug study within 30 day of enrollment
Prohibited Medications: