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| Name | Class |
|---|---|
| Swedish Cancer Foundation | OTHER |
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The aim of the project is to evaluate the oncological and functional outcome of the more extensive perineal dissection - i.e the extra levator resection - in abdominoperineal resections in patients with rectal cancer.
Hypothesis: Extra levator perineal resection reduces local recurrence three year postoperatively compared to traditional abdominoperineal resection and improves QoL 2-4 years postoperatively.
Low rectal cancer treated surgically by abdominoperineal resection (APR) has worse outcome than other rectal cancers operated with low anterior resection. In order to improve the outcome in the APR group a more extensive surgical procedure - the extra levator APR - has been suggested. This study aims to investigate both the oncological and the functional outcome of this method as compared to the traditional APR.
Method: All Swedish patients undergoing abdominoperineal resection for rectal cancer 2007-2009 will be analysed regarding operative technique (traditional or extra levator resection). Data on all patients regarding pre op TNM classification, pathological report and local recurrence will be collected from the Swedish Rectal Cancer registry. A validated QoL form will be sent to each patient to further investigate the functional outcome, health economy and Quality of Life 2-4 years postoperatively.
Data will be analysed regarding 3 year recurrence rate (primary endpoint) as well as functional result and QoL (secondary endpoints) in the two different groups - i.e traditional and extra levator APR.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Extralevator APR | The perineal part of the APR is done with the intent to create a cylindrically shaped specimen thus removing part of or the entire levator muscle with the specimen. | ||
| Traditional APR | The perineal part of the APR is performed with the intent to remove the tumour with CRM free of tumour and the levator left in place. |
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| Measure | Description | Time Frame |
|---|---|---|
| 3-year local recurrence | Local recurrence of rectal cancer 3 years after APR | 3 years postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative complications | postoperative morbidity: wound infection, deep infections, other infections, wound necrosis, pain, pneumonia, thrombosis | 30 days |
| Reoperation, readmittance and mortality |
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Inclusion Criteria:
Exclusion Criteria:
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All swedish patients registerd in the swedish rectalcancer registry undergoing APR 2007-2009
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| SSORG, Sahlgrenska Universitetssjukhuset, Område 2 | Gothenburg | Västra Götalandsregionen | 416 85 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27506432 | Derived | Gonzalez E, Holm K, Wennstrom B, Haglind E, Angenete E. Self-reported wellbeing and body image after abdominoperineal excision for rectal cancer. Int J Colorectal Dis. 2016 Oct;31(10):1711-7. doi: 10.1007/s00384-016-2628-0. Epub 2016 Aug 10. | |
| 26245948 | Derived | Asplund D, Prytz M, Bock D, Haglind E, Angenete E. Persistent perineal morbidity is common following abdominoperineal excision for rectal cancer. Int J Colorectal Dis. 2015 Nov;30(11):1563-70. doi: 10.1007/s00384-015-2328-1. Epub 2015 Aug 6. |
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| ID | Term |
|---|---|
| D012004 | Rectal Neoplasms |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
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Re-operation/s, length of hospital stay/s, re-admittance/s, mortality all within 12 months of primary surgery
| 12 months |
| Late morbidity | Late morbidity and functional disorders: prolonged wound healing, late infections, limping, pain, sitting problems, urinary incontinence, erectile dysfunction, stoma related dysfunction | 24-48 months postoperatively |
| Quality of Life | Patient experienced health and QoL 24-48 months postoperatively | 24-48 months postoperatively |
| Health economy | Health economy analysis of resource consumption | 24-48 months postoperatively |
| Stoma function | Assessment of stoma function related both to construction and surgical technique and patient position | 24-36 months postop |
| 22951192 | Derived | Prytz M, Angenete E, Haglind E. Abdominoperineal extralevator resection. Dan Med J. 2012 Sep;59(9):A4366. |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |