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The instrument that will be used in the study is the Murcia monocular Adaptive Optics Visual simulator (AOVIS-I). The system provides an objective characterization of the optical quality of the patient's eye by application of wave-front sensing technology. The optical condition of every eye is represented by its wave aberration. This characterization overcomes the current description based only in refractive errors. This provides an accurate description of the optics of the eye based on the assessment of the whole set of ocular aberrations. The particular wave-front sensor is of a Hartmann-Shack type. One characteristics of this wave-front sensor is its high dynamic range allowing measuring highly aberrated eyes, such as patients with keratoconus.
The complete procedure in one patient takes less than 5 minutes and is completely non-invasive.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Active Comparator | Measurement of aberrations in patients with keratoconus of grade 1 |
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| Group 2 | Active Comparator | patients with keratoconus of grade 2 |
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| Group 3 | Experimental | patients with keratoconus of grade 3 |
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| Group 4 | Experimental | patients with keratoconus of grade 4 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| classic aberrometer and aberrometer AOVIS-1 | Device | Measurement of aberrations in early stages (1 and 2) of keratoconus as compared aberrometer AOVIS-1 with a "classic aberrometer". |
| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome of the study is to evaluate the AOVIS-I and its wave-front sensor with high dynamic range for measuring high-order aberrations in patients with late stages (3 and 4) of keratoconus | at the 1st day |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the reliability of the measures in early stages (1 and 2) of keratoconus as compared with a "classic aberrometer". | at the 1st day | |
| To describe the measures obtained in advanced stages (3 and 4) of keratoconus. | at the 1st day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Francois Malecaze, MD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hopstial Toulouse | Toulouse | 31000 | France |
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| ID | Term |
|---|---|
| D007640 | Keratoconus |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
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| Aberrometer AOVIS-I | Device | Measurement of aberrations in high stages (3 and 4) of keratoconus. Objective characterization of the optical quality of the patient eye by application of wave-front sensing technology in late stage keratoconus The complete procedure in one patient takes less than 5 minutes in only one consultation and is completely non invasive. The optical measurements only involve the use of low power infrared laser |
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