Keloid Scarring: Treatment and Pathophysiology

Keloid Scarring:A Randomized Clinical and Laboratory Based Study on the Treatment and Differentiation Factors of the Local Disease

To clarify the mechanisms of Keloid scar formation.

Elucidate the action and therapeutic value of 5-FU in Keloid scar treatment

Identify the genetic link with Keloid scar formation.

Quantify the psychological/social impact in keloid scarring patients

Inclusion Criteria:

• Adult ( > 18 years old).
• Keloid scarring present.
• Able to understand and give informed consent.
• Patients giving informed consent to donate keloidal or non-affected skin when that is redundant after a procedure (i.e. BBR, Abdominoplasty).
• Patients with a strong familial pedigree of keloid scar formation.

Exclusion Criteria:

• Open wound at or proximity of the lesion

  • Infected lesion
  • Pregnant or planning pregnancy in the near future
  • Lactating (Breast Feeding)
  • Abnormal renal or liver function tests
  • Atrophic scars
  • Patient under 18 years of age
  • Immunocompromised
  • OR immunosuppressed