The purpose of this study is to assess whether patients with the classic form of Fabry disease have significantly less androgenic alopecia (male pattern baldness).

Objectives: To test the hypothesis that adult males with classic form of Fabry disease have a significantly lower incidence of androgenic alopecia than matched controls.

Study Population: 120 patients aged 20-64 with Fabry disease that have GLA mutations or alpha-galactosidase A activity associated with no residual enzyme activity and non-Fabry male controls of the same age range and the same number of non-Fabry controls.

Design: This is a cross-sectional study comparing the prevalence of androgenic alopecia in two groups of subjects.

Outcome Measures: The levels of the outcome will be no androgenic alopecia and frontal only androgenetic alopecia opposed to vertex only and frontal and vertex androgenetic alopecia.

Inclusion Criteria:

• Male patients with Fabry disease age 20-64 years old.
• Healthy male controls age 20-64 years old
• GLA gene mutations associated with the classic form of Fabry disease or having alpha-galactosidase A activity that is essentially zero
• Patients who freely agree to participate in this study and understand the nature, risks and benefits of this study and give their written informed consent.

Selected from specialy clinic