High Dose BAYA1040_Nifedipine: a Long Term Combination Study

A Multicenter, Open Label, Long Term Study of Oral BAYA1040_CR 80 mg (40 mg Bid) in Combination With Other Antihypertensives for 52 Weeks in Patients With Essential Hypertension

This is a clinical study evaluating the safety and efficacy of long term administration of oral BAYA1040_Nifedipine 80 mg/day (40 mg twice daily) with other antihypertensives in patients with essential hypertension who are not at target blood pressure by the combination of BAYA1040_Nifedipine 40 mg once daily and other antihypertensives.

Inclusion Criteria:

• 20 years or older
• Japanese male or female
• Outpatient with essential hypertension
• Patients who are treated with Adalat CR 40 mg od and at least one antihypertensive drug (other than Ca antagonists) for 4 weeks or more before entry in this study

Exclusion Criteria:

• Patients whose sitting diastolic blood pressure (DBP) is 110 mm Hg or more
• Patients with secondary hypertension or hypertensive emergency