The purpose of this study is to provide evidence of the safety, tolerance, and efficacy of ANT-1207 in the treatment of acne.

Inclusion Criteria:

• diagnosis of moderate to severe facial acne
• 15 to 40 papules and pustules, and 5 to 50 open and/or closed comedones
• no presence of nodules
• female subjects must be not pregnant and non-lactating

Exclusion Criteria:

• presence of 1 or more nodules
• use of topical steroids on the face 4 weeks prior and during the study
• use of systemic corticosteroids 6 weeks prior and during the study
• topical or systemic acne treatment in the 4 weeks prior to Baseline