Randomized Trial of Intranasal Versus Intravenous Naloxone in Level of Consciousness in Suspected Opioid Overdose

Study of Routs of Naloxone Administration for Opioid Overdosed Patients

The purpose of this study is to determine which route of administration is better for treatment of opioid overdosed patients

In intravenous drug abusers (IDUs), as a result of previous intravenous substance abuse, the predictable difficult cannulate exist and cause the delay administration of antidote therapy. Additionally, IDUs are also at increased risk of carrying blood borne infections that could be transmitted to healthcare workers through needle stick injuries. The investigators aimed to compare intranasal administration of naloxone with intravenous route.

Inclusion Criteria:

• Patients with the range of 15-50 years old

  • Who were suspicious to opioid overdoses based on history and having clinical appearance such as miotic pupils with loss of consciousness
  • Give response to naloxone with increasing the level of consciousness

Exclusion Criteria:

• Not giving response to naloxone and suspicious to have another reason for loss of consciousness