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The present study is designed to determine the mutational status of markers (TET2 and PLCb2, cytogenetic aberrations) together with methylation status of the above genes using bone marrow and matched buccal cell samples from MDS patients who necessitate to start a treatment (i.e. EPO, Lenalidomide, Azacytidine). All patients included in the study will be followed for at least 2 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with MYELODYSPLASTIC SYNDROMES | Patients diagnosed with MDS according to FAB, WHO and IPSS classifications. Patients who necessitate to start a treatment (i.e. EPO, Lenalidomide, Azacytidine). |
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| Measure | Description | Time Frame |
|---|---|---|
| Analyze the incidence of TET2 gene mutations and Validation of the prognostic potential of TET2 mutations and MPLA screening | Analyze the incidence of TET2 gene mutations in a series of MDS patients and describe the clinical status of patients carrying mutations Validation of the prognostic potential of TET2 mutations and MPLA screening on:
| 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Validation of the prognostic potential of TET2 mutations | Validation of the prognostic potential of Tet2 mutations on:
| 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with MDS detected by current diagnostic techniques (i.e., peripheral blood cytopenia, bone marrow morphology, cytogenetics andFISH analysis).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fortunato Morabito, MD | Contact | +390984681329 | omdsprotocol@fondazioneameliascorza.it | |
| Anna G Recchia, PhD | Contact | +390984681539 | omdsprotocol@fondazioneameliascorza.it |
| Name | Affiliation | Role |
|---|---|---|
| Fortunato Morabito, MD | Unità Operativa Complessa di Ematologia- Azienda Ospedaliera di Cosenza - Italy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| U.O. Ematologia - A.O. Spedali Civili di Brescia | Not yet recruiting | Brescia | Brescia | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19420352 | Background | Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, Malinge S, Yao J, Kilpivaara O, Bhat R, Huberman K, Thomas S, Dolgalev I, Heguy A, Paietta E, Le Beau MM, Beran M, Tallman MS, Ebert BL, Kantarjian HM, Stone RM, Gilliland DG, Crispino JD, Levine RL. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood. 2009 Jul 2;114(1):144-7. doi: 10.1182/blood-2009-03-210039. Epub 2009 May 6. | |
| 20195608 |
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| ID | Term |
|---|---|
| D009190 | Myelodysplastic Syndromes |
| ID | Term |
|---|---|
| D001855 | Bone Marrow Diseases |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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bone marrow and buccal cell samples
| Divisione di Ematologia Presidio Ospedaliero "A. Perrino" | Not yet recruiting | Brindisi | Brindisi | Italy |
|
| Divisione Clinicizzata di Ematologia con Trapianto di Midollo Osseo. Ospedale Ferrarotto. Azienda Policlinico | Not yet recruiting | Catania | Catania | Italy |
|
| S.O.C. Ematologia Azienda Ospedaliera di Catanzaro"Pugliese-Ciaccio" | Not yet recruiting | Catanzaro | Catanzaro | Italy |
|
| Unità Operativa Complessa di Ematologia- Azienda Ospedaliera di Cosenza | Recruiting | Cosenza | Cosenza | 87100 | Italy |
|
| U.O. Medicina Interna Universitaria 2 ed Ematologia Ospedale Civile San Salvatore | Not yet recruiting | Coppito | L'Aquila | 67010 | Italy |
|
| Unità di Ematologia, Ospedale Madonna delle Grazie, ASM | Not yet recruiting | Matera | Matera | Italy |
|
| Dipartimento di Oncologia, Oncoematologia e Unità Trapianto di Midollo Osseo, 'La Maddalena' | Not yet recruiting | Palermo | Palermo | Italy |
|
| U.O. di Ematologia Azienda Ospedaliera Universitaria Pisana | Not yet recruiting | Pisa | Pisa | Italy |
|
| Unità di Ematologia e Trapianto di Midollo Osseo, IRCCS-CROB, Centro di Riferimento Oncologico della Basilicata | Not yet recruiting | Rionero in Vulture | Potenza | Italy |
|
| Divisione Ematologia - Azienda Ospedaliera "Bianchi-Melacrino-Morelli" | Not yet recruiting | Reggio Calabria | Reggio Calabria | Italy |
|
| Dipartimento di Biotecnologie Cellulari ed Ematologia, Università La Sapienza | Not yet recruiting | Roma | Roma | 00161 | Italy |
|
| U.O.C. di Ematologia - Policlinico Agostino Gemelli- | Not yet recruiting | Roma | Roma | Italy |
|
| U. O. C. Ematologia - Azienda Ospedaliera Sant'Andrea | Not yet recruiting | Rome | Roma | 00189 | Italy |
|
| Background |
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