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The object of the study is to investigate whether all included patients receive treatment that is effective against all bacteria that are defined as sensitive to meropenem with the current treatment regimen. Will the investigators findings motivate routine monitoring of plasma concentrations in children receiving meropenem? Up to 50 patients will be included in the study, and all participants are children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children receiving meropenem | Children aged from 3 months to 18 years that receive treatment with meropenem. |
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| Measure | Description | Time Frame |
|---|---|---|
| We will determine how many of the patients in our material that have plasma concentrations of meropenem above 8 mg/l for at least 40% and 75% of the time. | 1 dosing interval (8 hours) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients at the Pediatric medical ward.
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| Name | Affiliation | Role |
|---|---|---|
| Odd Brørs, Dr Med | Oslo University Hospital | Study Director |
| Margrete L Burns, BMed | Oslo univeristy hospital | Study Chair |
| Øystein Riise, PhD | Oslo University Hospital | Study Chair |
| Tore Abrahamsen, Dr Med | Oslo univeristy hospital | Study Chair |
| Gaut Gadeholt, Dr Med | Oslo University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo univeristy hospital, Rikshospitalet | Oslo | 0424 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17581801 | Background | Ikeda K, Ikawa K, Morikawa N, Miki M, Nishimura S, Kobayashi M. High-performance liquid chromatography with ultraviolet detection for real-time therapeutic drug monitoring of meropenem in plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 1;856(1-2):371-5. doi: 10.1016/j.jchromb.2007.05.043. Epub 2007 Jun 6. |
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| ID | Term |
|---|---|
| D001424 | Bacterial Infections |
| ID | Term |
|---|---|
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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Two blood samples are taken from each included patient. (Each 2 ml heparin full blood).