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| Name | Class |
|---|---|
| NeoStrata Company, Inc. | INDUSTRY |
| Penn Center for AIDS Research (CFAR) | UNKNOWN |
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Many human immunodeficiency virus (HIV)-positive children are afflicted with diffuse flat warts that have been recalcitrant to multiple treatments.The aim of this prospective study was to evaluate the efficacy, safety and tolerability of 15% glycolic acid lotion (NeoStrata) for treatment of flat warts in HIV-positive children in Botswana. Additionally, the investigators characterized the flat warts in this population, including Human Papillomavirus (HPV) type(s) and degree of immunosuppression within the patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Glycolic acid | Experimental | All who met the study criteria commenced once daily use of 15% glycolic acid lotion. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glycolic acid | Drug | Those who met the study criteria commenced once daily use of 15% glycolic acid lotion to the face and/or dorsal hands, with an increase to twice daily application as tolerated after two weeks of use. |
| Measure | Description | Time Frame |
|---|---|---|
| Treatment efficacy of 15% glycolic acid lotion for flat warts | Our primary objective is to determine the efficacy of 15% glycolic acid lotion for improving the cosmetic appearance of flat warts in HIV infected children and young adults on antiretroviral therapy. | Patients were evaluated every two weeks for eight weeks and monthly for the next eight weeks, for a total monitoring period of 16 weeks. |
| Safety and tolerability of 15% glycolic acid lotion for flat warts | Patients were evaluated for possible side effects of the topical medication, including erythema, scaling, burning, and irritation of the skin in the area applied. | Patients were evaluated every two weeks for eight weeks and monthly for the next eight weeks, for a total monitoring period of 16 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| HPV typing in EV-like flat warts | Characterize the HPV types in the flat warts in this population. | Biopsies were taken at the first visit, and the HPV typing was performed on all samples after the 16 week monitoring period was complete. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Princess Marina Hospital | Gaborone | Botswana |
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| ID | Term |
|---|---|
| C031149 | glycolic acid |
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