Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this study is to determine whether a powerful technique of noninvasive brain stimulation, transcranial direct current stimulation (tDCS), could reduce cigarette smoking and constitute a treatment of tobacco addiction.
Tobacco is estimated to cause more than 5 millions yearly deaths in the developed world. Although most smokers would like to quit, relapse rates remain high. It seems that this relapse is linked with the process of craving, which is a powerful desire to smoke elicited by smoking deprivation or exposure to situations or cues that are associated with smoking. Neuroimaging studies have shown that the dorsolateral prefrontal cortex (DLPFC), and especially the right part, is critically involved in processing the craving of smoking. Increasing the activity of the DLPFC by noninvasive brain stimulation has been demonstrated to be effective in decreasing craving symptoms in cigarette smokers.
The aim of this study is to determine whether a powerful technique of noninvasive brain stimulation, transcranial direct current stimulation (tDCS), could reduce cigarette smoking. tDCS is a painless and safe brain stimulation method capable of modulating cortical excitability. The nature of these modulations depends on stimulation polarity: anodal tDCS is thought to cause neuronal depolarisation and thus enhancing cortical excitability whereas cathodal stimulation is proposed to reduce excitability. The investigators hypothesize that anodal tDCS applied repetitively to the right DLPFC could constitute a treatment of tobacco addiction. Therefore, the investigators will conduct a sham-tDCS-controlled, randomized, double-blind study.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sham tDCS | Sham Comparator | sham transcranial direct current stimulation The anode (7 x 5 cm) is placed on the right dorsolateral prefrontal cortex. A large cathode (10 x 10cm) is placed on the left occipital region |
|
| active tDCS | Active Comparator | active anodal tDCS over the right dorsolateral prefrontal cortex The anode (7 x 5 cm) is placed on the right dorsolateral prefrontal cortex. A large cathode (10 x 10cm) is placed on the left occipital region Intensity of the stimulation: 2 mA Duration of the stimulation: 20 min 10 sessions, 2 per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sham tDCS | Procedure | sham condition as delivered by the stimulator "study mode" (2mA during 40s and brief current pulses until the end of the stimulation) 20 minutes, 10 sessions, 2 per day |
| Measure | Description | Time Frame |
|---|---|---|
| Smoking | Self-reported number of cigarettes smoked each day | Baseline (three days before starting tDCS regimen) to one-month after |
| Measure | Description | Time Frame |
|---|---|---|
| Exhaled carbon monoxide | measured using a CO monitor (MicroCo, Milford, MA, USA). | Baseline, one-week (after the last tDCS session) and one-month later |
| Craving | measured using a 5-item Likert-type scale questionnaire of smoking urge |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| JEROME BRUNELIN, PhD | Hopital le Vinatier | Study Director |
| Emmanuel POULET, MD, PhD | Hopital le Vinatier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital le Vinatier | Bron | 69677 | France |
Not provided
| ID | Term |
|---|---|
| D016739 | Behavior, Addictive |
| D012907 | Smoking |
| ID | Term |
|---|---|
| D003192 | Compulsive Behavior |
| D007175 | Impulsive Behavior |
| D001519 | Behavior |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| active tDCS | Procedure | anodal tDCS applied over the right DLPFC 2mA, 20minutes, 10 sessions, 2 per day |
|
| For each of the 10 tDCS sessions: Baseline and 0 hour post-tDCS (immediately after) |
| fMRI brain reactivity during a smoking cue-reactivity task | measured using an event-related fMRI paradigm | Baseline and one-week (after the last tDCS session) |