Beyond Intuition: Quantifying and Understanding the Signs and Symptoms of Fever
Beyond Intuition: Quantifying and Understanding the Signs and Symptoms of Fever
Background:
- Fever is a common symptom of illness, but it can involve many signs (a signal that something is not right in the body that can be seen by others, such as vomiting) and symptoms (a signal that something is not right in the body that are felt only by the person, such as pain) that may differ depending on the type of illness involved. Researchers are interested in studying individuals who have a fever to examine how often these signs and symptoms are experienced by patients.
Objectives:
- To identify and evaluate the signs and symptoms of fever and examine their frequency in individuals who have fever.
Eligibility:
- Individuals at least 8 years of age who are admitted to the NIH Clinical Center and have a fever (body temperature of at least 38 degrees Celsius/100.4 degrees Fahrenheit).
Design:
Background:
Fever is one of the most prevalent signs in hospitalized patients, signaling the activation of the immune system.
There is little empiric evidence related to symptoms or signs that accompany changes in body temperature.
Understanding the nature, timing and relationship of patient signs and symptoms of fever will provide insight into the febrile process and guide more informed treatment.
Objectives:
The protocol is divided into two phases:
Phase I
-To develop and implement a simple clinical tool for assessing and documenting patient-reported signs and symptoms of fever.
Phase II
-To describe the prevalence and relationship of signs and symptoms that accompanies a febrile state and related patterns of change over time.
Eligibility:
Phase I
Phase II
Design:
Phase I
-Descriptive study involving qualitative interviews and chart reviews from medical surgical inpatients. Two types of interviews with two different sets of patients will be conducted. The maximum number of research participants for this phase will be 65. The final sample size will be determined based on the point of saturation, defined as four consecutive interviews during which no new signs or symptoms associated with fever are identified. The second set of interviews will involve 20 to 30 new research participants, including at least 5 patients less than 18 years of age who will review a list of signs and symptoms of fever for comprehension and clarity to inform the final list and determine the terminology to be used in the FAST.
Study of the Febrile Assessment Tool (FAST)
-Test of the FAST in 120 patients. Before placing the FAST in the electronic record (Clinical Research Information System-CRIS) this new assessment tool will be used in approximately 120 patients during routine vital sign measurements. Patients admitted to the surgical oncology unit (3NW) will be consented and followed with collection of the FAST assessments
Education Implementation
Phase II
Adult and pediatric medical-surgical patients hospitalized in the Clinical Center, NIH admitted to 3NE (oncology/ transplant), 3NW (surgical oncology) and 1NW (pediatrics).
Oriented to person, time and place at time of interview
Active fever (body temperature greater than or equal to 38.0 Celsius), treated or untreated, within the last 12 hours.
Willingness to participate in a short interview (15-20 minutes) about their symptoms
Understands and speaks English
Age 8 years and older
INCLUSION CRITERIA FOR STUDY OF FEBRILE ASSESSMENT TOOL:
Adult (18 years of age or greater) medical-surgical patients hospitalized at the Clinical Center and admitted to 3NW.
Oriented to person, time and place at time of admission
Willingness to be asked about their symptoms of fever during vital signs assessment
Understands and speaks English
INCLUSION CRITERIA PHASE II:
Inpatients admitted to the Clinical Center
Age 8 years and older