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The purpose of this study is to examine the natural history of chronic urticaria in children and to identify the predictors for chronic urticaria remission.
A Prospective cohort study of 92 children who were diagnosed with chronic urticaria to investigate the natural course of chronic urticaria and to identify predictors of disease remission.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic urticaria | Chronic urticaria, Natural history |
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| Measure | Description | Time Frame |
|---|---|---|
| Duration of Urticaria Until Remission Since Chronic Urticaria Was Diagnosed. | Remission rates at 1, 3 and 5 years after the onset of symptoms of chronic urticaria. Description in details: Actually, this study have been started in March 2003 and finally done in March 2009, which would be totally 6 years. We eventually decided to report the rate of CU remissions only at 1, 3 and 5 years after the onset of symptoms because this would be the common interval time of CU symptoms that patients needed to know how long they should have those CU symptoms or how many of them would go away their symptoms within 1, 3 or 5 years. Another reason is that the remission rate of CU between 5 and 6 years was not significantly different, so it might not need to be reported. | 6 years |
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Inclusion Criteria:
Exclusion Criteria:
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Pediatric allergy clinic, Siriraj Hospital Mahidol University, Thailand, Children 4-15 years of age with chronic urticaria.
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| Name | Affiliation | Role |
|---|---|---|
| Orathai Piboonpocanun, Prof. | Siriraj Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University | Bangkok | Bangkok | 10700 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25023899 | Result | Chansakulporn S, Pongpreuksa S, Sangacharoenkit P, Pacharn P, Visitsunthorn N, Vichyanond P, Jirapongsananuruk O. The natural history of chronic urticaria in childhood: a prospective study. J Am Acad Dermatol. 2014 Oct;71(4):663-8. doi: 10.1016/j.jaad.2014.05.069. Epub 2014 Jul 11. |
| Label | URL |
|---|---|
| The natural history of chronic urticaria in childhood: a prospective study. | View source |
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| ID | Title | Description |
|---|---|---|
| FG000 | Chronic Urticaria | Chronic urticaria, Natural history |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
Remission period, chronic urticaria
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| ID | Title | Description |
|---|---|---|
| BG000 | Chronic Urticaria | Chronic urticaria, Natural history |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Children 4-15 years of age |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Duration of Urticaria Until Remission Since Chronic Urticaria Was Diagnosed. | Remission rates at 1, 3 and 5 years after the onset of symptoms of chronic urticaria. Description in details: Actually, this study have been started in March 2003 and finally done in March 2009, which would be totally 6 years. We eventually decided to report the rate of CU remissions only at 1, 3 and 5 years after the onset of symptoms because this would be the common interval time of CU symptoms that patients needed to know how long they should have those CU symptoms or how many of them would go away their symptoms within 1, 3 or 5 years. Another reason is that the remission rate of CU between 5 and 6 years was not significantly different, so it might not need to be reported. | Children 4-15 years old with chronic urticaria | Posted | Number | percentage of participants | 6 years |
|
6 years. Actually, this study is the prospective observational study of chronic urticaria for over 6 years regarding only the remission of the disease.
Since we did not add any intervention into the participants, therefore, we did not observe any serious or non-serious adverse events other than the activity or remission of chronic urticaria. However, if we consider as the Total Number of Participants at Risk, the number should be "92 participants" or "100%".
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Chronic Urticaria | Chronic urticaria, Natural history |
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| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Remission of chronic urticaria after 1 year of symptoms | Skin and subcutaneous tissue disorders | Non-systematic Assessment | Remission of chronic urticaria (CU) after 1 year of the onset of symptoms was considered if symptoms did not recur for at least 12 months without medication after 1 years of CU symptoms. |
This study did not perform basophil histamine releasing assay to identify the existence of functional autoantibodies, since there was no available laboratory to do this test.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Professor Orathai Jirapongsananuruk, Director of Clinical Trials | Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University | 024197000 | siojr@mahidol.ac.th |
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| ID | Term |
|---|---|
| D000080223 | Chronic Urticaria |
| ID | Term |
|---|---|
| D014581 | Urticaria |
| D017445 | Skin Diseases, Vascular |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| Median |
| Full Range |
| Years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
Chronic urticaria, Natural history
|
|
| 0 |
| 92 |
| 62 |
| 92 |
|
| Remission of chronic urticaria after 3 years of symptoms | Skin and subcutaneous tissue disorders | Non-systematic Assessment | Remission of chronic urticaria (CU) after 3 years of the onset of symptoms was considered if symptoms did not recur for at least 12 months without medication after 3 years of CU symptoms. |
|
| Remission of chronic urticaria (CU) after 5 years of symptoms | Skin and subcutaneous tissue disorders | Non-systematic Assessment | Remission of chronic urticaria (CU) after 5 years of the onset of symptoms was considered if symptoms did not recur for at least 12 months without medication after 5 years of CU symptoms. |
|
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| D006969 |
| Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |