The purpose of this study is to find out the effects of hypoglycemia on cognition in healthy individuals and how well changes in (interstitial) tissue glucose levels correlate with changes in cognitive function as compared to blood glucose levels.

Subjects will undergo hypoglycemic clamps during which interstitial glucose will be measured and cognitive function will be assessed.

Inclusion Criteria:

• non obese (BMI <30), ages 18-50

Exclusion Criteria:

• renal or hepatic failure

• cancer or lymphoma

• malabsorption or malnourishment

• hypercortisolism

• alcoholism or drug abuse

• anemia

• eating disorder or depression

• coronary artery disease

• Arrhythmias

• hypertension

• on medications known to affect the blood glucose to be measured such as

• glucocorticoids

• on blood thinning agents

  • Pregnant women, breastfeeding women and women who want to become pregnant in the next 6 months will be excluded from the study.
  • Subjects who have donated blood two weeks prior to the study.
  • Allergies to pig derived products (Heparin will be used)