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This project aimed to explore novel methods of detecting small blood vessel disease in a paediatric population with type 1 diabetes mellitus. To do this the techniques of Nailfold capillaroscopy, laser Doppler flowmetry, retinal (eye) vessel analysis and 24-hr Ambulatory Blood Pressure Monitoring were used. Each of these techniques investigated different areas of small blood vessels around the body.
It was hypothesized that in a paediatric population with type 1 diabetes mellitus the novel investigations would be associated with small blood vessel disease and that widespread changes to these blood vessels would be detected through associations between the different novel investigations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 1 Diabetes Paediatric | Paediatric patients aged 8-18 with diagnosed Diabetes Mellitis Type 1 attending paediatric clinic at John Hunter Hospital. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Video Nailfold Capillaroscopy | Procedure | Single session of video Nailfold Capillaroscopy wit KKK technology |
|
Inclusion Criteria:
Exclusion Criteria:
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Participants were recruited from the John Hunter Children's Hospital paediatric diabetes clinic. They were between the ages of 8-18 years old.
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| Name | Affiliation | Role |
|---|---|---|
| Rani Bhatia, MD | John Hunter Children's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| John Hunter Children's Hospital | New Lambton | New South Wales | 2305 | Australia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24093770 | Derived | Hosking SP, Bhatia R, Crock PA, Wright I, Squance ML, Reeves G. Non-invasive detection of microvascular changes in a paediatric and adolescent population with type 1 diabetes: a pilot cross-sectional study. BMC Endocr Disord. 2013 Oct 5;13:41. doi: 10.1186/1472-6823-13-41. |
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| Ambulatory 24 hr Blood Pressure Monitoring | Device | 24 hr upper arm cuff measurement of Blood Pressure |
|
| Fundoscopy of eyes | Procedure | examination of microvascular health of eye with the use of opthalmoscope |
|
| Laser Doppler Flowmetry | Procedure | Examination of vascular flow |
|
| ID | Term |
|---|---|
| D003922 | Diabetes Mellitus, Type 1 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D015924 | Blood Pressure Monitors |
| D017078 | Laser-Doppler Flowmetry |
| ID | Term |
|---|---|
| D019722 | Sphygmomanometers |
| D019719 | Diagnostic Equipment |
| D004864 | Equipment and Supplies |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012212 | Rheology |
| D008919 | Investigative Techniques |
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