Motor Training and White Matter in Multiple Sclerosis (MS)

The Influence of a tDCS Combined Long-term Motor Training Program on Structural White Matter Changes in the Brain, Functionality and Psychological Outcome Measures in Multiple Sclerosis.

In the current study the researchers will firstly investigate whether a bimanual coordination training protocol (20 min/day, for 8 consecutive weeks) correlates with changes in white matter architecture and improved upper-limb functionality in patients with multiple sclerosis. Secondly, the researchers predict that motor learning is more efficient when it is combined with anodal transcranial direct current (tDCS) stimulation on the left primary motor cortex.

Inclusion Criteria:

• Expanded Disability Status Scale (EDSS) scores between 2 and 6.5
• Stable MS (no relapse during the last 3 months before study onset)
• age: between 18 and 68 years

Exclusion Criteria:

• Patients with other pathologies associated with peripheral and/or central sensory dysfunction or under psychotropic or antiepileptic medication.
• Standard TMS/tDCS and MRI exclusion criteria (safety questionnaires)