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| Name | Class |
|---|---|
| Ministry for Food, Agriculture, Forestry and Fisheries, Korea | OTHER_GOV |
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The purpose of this study is to evaluate the antioxidant effect of Plantago asiatica L. extract in subjects with mild hyperlipidemia.
The purpose of this study is to evaluate an acute effect of Plantago asiatica L. extract consumption on antioxidative biomarkers in subjects with mild hyperlipidemia. Subjects will intake Plantago asiatica L. extract with a high fat meal for oxidative stress loading. Antioxidative biomarkers will be measured after single-dose administration of Plantago asiatica L. extract.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| • Plantago asiatica L. extract 5g | Experimental |
| |
| Plantago asiatica L. extract 10g | Experimental |
| |
| Plantago asiatica L. extract 20g | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Plantago asiatica L. extract 5g | Dietary Supplement | Liquid (80g) containing Plantago asiatica L. extract 5g |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comet assay after single-dose consumption of Plantago asiatica L. extract | measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma FRAP | measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes) | |
| Plasma MDA | measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes) | |
| Plasma FFA |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Oran Kwon, Ph.D | Ewha Womans University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ewha Womans University / Hanaro Medical Foundation | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 2193855 | Background | Sun Y. Free radicals, antioxidant enzymes, and carcinogenesis. Free Radic Biol Med. 1990;8(6):583-99. doi: 10.1016/0891-5849(90)90156-d. | |
| 12583244 | Background | Liu X, Wu X, Huang H, Zhong S, Lai X, Cao L. [Herbalogical study on Plantago asiatica L]. Zhong Yao Cai. 2002 Jan;25(1):46-8. Chinese. |
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| Plantago asiatica L. extract 10g | Dietary Supplement | Liquid (80g) containing Plantago asiatica L. extract 10g |
|
| Plantago asiatica L. extract 20g | Dietary Supplement | Liquid (80g) containing Plantago asiatica L. extract 20g |
|
| Placebo | Dietary Supplement | Liquid (80g) without Plantago asiatica L. extract |
|
| measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes) |
| Plasma ox-LDL | measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes) |
| Plasma erythrocyte SOD | measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes) |
| Plasma triglyceride | measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes) |
| 18167045 | Background | Choi SY, Jung SH, Lee HS, Park KW, Yun BS, Lee KW. Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract. Phytother Res. 2008 Mar;22(3):323-9. doi: 10.1002/ptr.2316. |
| 17697428 | Background | Chung MJ, Park KW, Kim KH, Kim CT, Baek JP, Bang KH, Choi YM, Lee SJ. Asian plantain (Plantago asiatica) essential oils suppress 3-hydroxy-3-methyl-glutaryl-co-enzyme A reductase expression in vitro and in vivo and show hypocholesterolaemic properties in mice. Br J Nutr. 2008 Jan;99(1):67-75. doi: 10.1017/S0007114507798926. Epub 2007 Aug 15. |
| 15120459 | Background | Xu C, Luo L, Tan RX. Antidepressant effect of three traditional Chinese medicines in the learned helplessness model. J Ethnopharmacol. 2004 Apr;91(2-3):345-9. doi: 10.1016/j.jep.2004.01.012. |
| Background | Lee SJ. Korean folk medicine. Publishing center of Seoul National Unicersity, Seoul. P 130, 1966 |
| Background | Jeong CH, Bae YI, Shim KH, Choi JS. DPPH radical scavenging effect and antimicrobial activities of Plantain (Plantago asiatica L.) extracts. J Korean Soc Food Sci Nutr 33(10): 1601-1605, 2004 |