Aim of the study is to evaluate toxicity in breast cancer patients treated with two different doses of Intra Operative Radiotherapy

Inclusion Criteria:

• Non lobular epithelial breast carcinoma, excised with standard quadrantectomy
• Age ≥ 45 and < 85
• Tumor major diameter ≤ 2.5 cm
• Negative surgical margins (≥ 5 mm)
• Willingness to undergo follow up examinations
• Willingness to undergo imaging examinations (MRI, mammograms, ultrasonography)
• Signed informed consent

Exclusion Criteria:

• Ductal carcinoma in situ or lobular carcinoma
• Extensive intraductal component (greater than 25%) or intraductal carcinoma with microinvasion
• Serious concomitant disease or any disorder or condition (such as psychiatric or addictive disorders) that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
• Pregnancy or lactation at the time of enrolment proposal (if necessary, during the trial patients must use effective contraceptive device)
• Collagen vascular disorders