Comparison of Immunosuppression on Progression of Arteriosclerosis in Renal Transplantation

Randomised Comparison of Two Different Immunosuppressive Regimens on Progression of Arteriosclerosis in Renal Transplant Patients.

To compare in a prospective randomised way the effect of two different immunosuppressive regimens - mTOR-based regimen or CNI-based regimen - on the progression of coronary artery calcification in renal transplant patients measured at baseline, 1, 2, and 3 years after transplantation.

Inclusion Criteria:

• Age between 18-75 yr
• Willingness to provide written informed consent
• Ability to understand the study procedures

Exclusion Criteria:

• Life expectancy < 3 months
• Claustrophobia
• Allergy to iodinated contrast
• Treatment incompliance
• Pregnancy
• Highly HLA-sensitized patients
• Severe dyslipidemia or proteinuria
• Severe leucopenia or thrombocytopenia
• GFR < 30 ml/min