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| ID | Type | Description | Link |
|---|---|---|---|
| 2009-011605-16 | EudraCT Number |
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insufficient patients enrolled
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| Name | Class |
|---|---|
| UMC Utrecht | OTHER |
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To compare in a prospective randomised way the effect of two different immunosuppressive regimens - mTOR-based regimen or CNI-based regimen - on the progression of coronary artery calcification in renal transplant patients measured at baseline, 1, 2, and 3 years after transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| everolimus-based immunosuppression | Experimental | immunosuppression with everolimus, prednisone and mycophenolate |
|
| standard immunosuppression | Active Comparator | immunosuppression with tacrolimus, prednisone and mycophenolate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| everolimus | Drug | comparison of everolimus-based and CNI-based immunosuppression |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in coronary artery calcification score | Comparison in a randomised way the effect of a calcineurin-based immunosuppressive regimen with an mTOR-based regimen on progression of coronary calcification on renal transplant patients. The results of this study will provide more insight in protection against cardiovascular disease in renal transplant patients. | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Franka E van Reekum, MD | UMC Utrecht | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Center Utrecht | Utrecht | 3584 CX | Netherlands |
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| ID | Term |
|---|---|
| D000068338 | Everolimus |
| ID | Term |
|---|---|
| D020123 | Sirolimus |
| D018942 | Macrolides |
| D007783 | Lactones |
| D009930 | Organic Chemicals |
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