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| Name | Class |
|---|---|
| Federal Emergency Management Agency | FED |
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The investigators hypothesize that
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute, Aspirin | Active Comparator | 81 mg asprin provided 30 minutes prior to firefighting- Acute single dosage |
|
| Acute, Placebo | Placebo Comparator | Acute single dosage of placebo provided 30 minutes prior to firefighting |
|
| Chronic, Aspirin | Active Comparator | 81 mg asprin provided prior to firefighting- 14 day dosage |
|
| Chronic, Placebo | Placebo Comparator | 14 day dosage of placebo provided prior to firefighting |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 81 mg enteric coated aspirin | Drug | 81 mg enteric coated aspirin will be provided both as an acute dosage immediately prior to firefighting (1 hour pre-activity) and as a 14 day dosage prior to firefighting |
| Measure | Description | Time Frame |
|---|---|---|
| Vascular function | Vascular function will be assessed via pulse wave analysis, pulse wave velocity, carotid artery compliance, beta stiffness index, forearm rsistance artery vasodilatory capacity, and brachial artery blood flow. | Less than 60 minutes before initiating firefighting activity |
| Hemostatic balance | Blood samples will be collected by a trained phlebotomist from the antecubital vein directly into vacutainers with little or no stasis using a 21-gauge needle. Samples will be used to quantify platetlet number and function, fibrinogen, prothrombin and partial thromboplastin time, t-PA and PAI-1 activities and antigen | Less than 60 minutes before initiating firefighting activity |
| Inflammatory and Oxidative Stress markers | CRP,Intercellular adhesion molecule (ICAM)-1, IL-6, MMP-9, TIMP-1, TIMP-2,8-iso-prostaglandin F2a, soluble P-selectin | Less than 60 minutes before initiating firefighting activity |
| Vascular function | Vascular function will be assessed via pulse wave analysis, pulse wave velocity, carotid artery compliance, beta stiffness index, forearm rsistance artery vasodilatory capacity, and brachial artery blood flow. | Less than 60 minutes after completing 20 minutes of firefighting activity |
| Hemostatic balance | Blood samples will be collected by a trained phlebotomist from the antecubital vein directly into vacutainers with little or no stasis using a 21-gauge needle. Samples will be used to quantify platetlet number and function, fibrinogen, prothrombin and partial thromboplastin time, t-PA and PAI-1 activities and antigen | Less than 60 minutes after completing 20 minutes of firefighting activity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gavin P Horn, PhD | University of Illinois Urbana-Champaign | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Illinois Fire Service Institute | Champaign | Illinois | 61820 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31090673 | Derived | Smith DL, Friedman NMG, Bloom SI, Armero WL, Pence BD, Cook MD, Fernhall B, Horn GP, Woods J. Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters. J Occup Environ Med. 2019 Jul;61(7):617-622. doi: 10.1097/JOM.0000000000001626. | |
| 26057939 | Derived | Lane-Cordova AD, Ranadive SM, Yan H, Kappus RM, Sun P, Bunsawat K, Smith DL, Horn GP, Ploutz-Snyder R, Fernhall BO. Effect of Aspirin Supplementation on Hemodynamics in Older Firefighters. Med Sci Sports Exerc. 2015 Dec;47(12):2653-9. doi: 10.1249/MSS.0000000000000713. |
| Label | URL |
|---|---|
| Illinois Fire Service Institute home page | View source |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D001241 | Aspirin |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
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|
| Inflammatory and Oxidative Stress markers | CRP,Intercellular adhesion molecule (ICAM)-1, IL-6, MMP-9, TIMP-1, TIMP-2,8-iso-prostaglandin F2a, soluble P-selectin | Less than 60 minutes after completing 20 minutes of firefighting activity |
| D006841 |
| Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |