Adiponectin and Circulating Progenitor Cells (CPC) Function

Adiponectin Promotes the Migration of Circulating Progenitor Cells Through p38-mediated Induction of the CXCR4 Receptor

Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.

Inclusion Criteria:

• ≤ 75 years of age
• stable coronary artery disease
• preserved left ventricular function
• physical work capacity of ≥ 50
• successful elective percutaneous coronary intervention at study begin

Exclusion Criteria:

• diabetes mellitus
• hypercholesterolemia
• untreated hypertension
• smoking
• myocardial infarction within the last 4 weeks
• significant stenosis of the left main coronary artery