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| ID | Type | Description | Link |
|---|---|---|---|
| DMR-IRB-242 | Other Identifier | China Medical University Hospital |
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The AUC240, AUC360, and AUC480 of titrated oral misoprostol are greater than traditional oral misoprostol.
The primary outcomes measures of the study are the area under the curve of serum concentration of misoprostol acid against time up to 240, 360 and 480 minutes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hourly misoprostol | Experimental | 20 microgram misoprostol intake per hour |
|
| traditional misoprostol | Active Comparator | 80 microgram misoprostol intake per 4 hours |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Misoprostol | Drug | 20 microgram PO per hour for 8 doses or 80 microgram PO per 4 hours for 2 doses |
|
| Measure | Description | Time Frame |
|---|---|---|
| AUC480 (the area under the curve of serum concentration of misoprostol acid against time up to 480 minutes) | 480 min post start of oral misoprostol administration |
| Measure | Description | Time Frame |
|---|---|---|
| AUC240 (the area under the curve of serum concentration of misoprostol acid against time up to 240 minutes) | 240 min post start of oral misoprostol administration | |
| AUC360 (the area under the curve of serum concentration of misoprostol acid against time up to 360 minutes) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shi-Yann Cheng, M.D. | China Medical University Beigang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China Medical University Beigang Hospital | Yunlin Xian | Taiwan | 651 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11821273 | Background | Tang OS, Schweer H, Seyberth HW, Lee SW, Ho PC. Pharmacokinetics of different routes of administration of misoprostol. Hum Reprod. 2002 Feb;17(2):332-6. doi: 10.1093/humrep/17.2.332. | |
| 9207820 | Background | Zieman M, Fong SK, Benowitz NL, Banskter D, Darney PD. Absorption kinetics of misoprostol with oral or vaginal administration. Obstet Gynecol. 1997 Jul;90(1):88-92. doi: 10.1016/S0029-7844(97)00111-7. |
| Label | URL |
|---|---|
| China Medical University Beigang Hospital | View source |
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| ID | Term |
|---|---|
| D016595 | Misoprostol |
| ID | Term |
|---|---|
| D011459 | Prostaglandins E, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
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| 360 min post start of oral misoprostol administration |
| D005231 |
| Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |