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| Name | Class |
|---|---|
| European Foundation for the Study of Diabetes | OTHER |
| Medical University of Graz | OTHER |
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Bariatric operations such as the gastric bypass procedure provide a unique in vivo model of improvement of pathological beta cell function. The presented double-centre study aims to comprehensively investigate different aspects of beta cell function in patients with type 2 diabetes (T2DM) with a wide range of disease duration after gastric bypass. In parallel, our project will address the aspects of changes in enteroinsular and adipoinsular axes as well as the early and late changes of other defined parameters after gastric bypass surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| T2DM patients before gastric bypass surgery | Active Comparator | oral glucose tolerance test , botnia clamp, preoperative as well as 10 days postoperative and 1 year postoperative, gastric bypass surgery. |
|
| Non-diabetic patient before gastric bypass surgery | Active Comparator | oral glucose tolerance test , botnia clamp, preoperative as well as 10 days postoperative and 1 year postoperative, gastric bypass surgery. |
|
| non diabetic patients, non-bariatric abdominal surgery | Active Comparator | oral glucose tolerance test , botnia clamp, elective laparoscopic abdominal surgery. |
|
| severely obese T2DM patients following a very low caloric diet | Active Comparator | oral glucose tolerance test , botnia clamp, before as well after following a very low caloric diet. Very low caloric diet. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gastric bypass surgery | Procedure |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Acute insulin response (AIR) to glucose during IVGTT will be used as a primary variable characterizing the beta cell function | 10 days after gastric bypass |
| Measure | Description | Time Frame |
|---|---|---|
| OGTT calculations and modelling describing beta cell response to oral glucose load; Insulin and C-peptide areas under the curve (AUCs) during OGTT quantifying the incretin effect. | 10 days after gastric bypass | |
| • Plasma concentrations and adipose tissue expression of selected adipokines and inflammatory cytokines characterizing the adipoinsular axis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bernd Schultes, Prof. | Interdisciplinary Obesity Center, Kantonal Hospital St. Gallen, Switerland | Principal Investigator |
| Thomas Pieber, Prof. | Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Austria | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, MEdical University of Graz, Austria | Graz | 8036 | Austria |
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| abdominal surgery |
| Procedure |
|
| very low caloric diet | Behavioral |
|
| 10 days after gastric bypass |
| Interdisciplinary Obesity Center, Kantonal Hospital St. Gallen, Switzerland | Sankt Gallen | 9400 | Switzerland |
| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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