The hypothesis of the study is to evaluate whether ascorbic acid is able to clear totally implanted central venous catheter

Totally implanted catheter is often occluded and thrombolytic drugs are usually used to restore permeability. In Brazil, the ascorbic acid has been used successfully by a service specialist in cancer treatment. However, no literature on international research that evaluates the efficacy and safety of this procedure. That was why it was decided to develop this research.

Inclusion Criteria:

• Diagnosis of partial or complete obstruction of the totally implanted central venous catheter;
• No signs of inflammation in the area of the port.

Exclusion Criteria:

• Use of oral anticoagulants or intravenous administration in the last seven days;
• Diagnostic and / or suspected infection in the totally implanted central venous catheter;
• Rupture, displacement or fissure of the totally implanted central venous catheter;
• Presence of thrombosis in the vein where the catheter is inserted.