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| Name | Class |
|---|---|
| Technion, Israel Institute of Technology | OTHER |
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The metabolic syndrome is a collection of related risk factors that predispose to the development of type 2 diabetes Mellitus and cardiovascular disease. The investigators will examine the hypothesis that the metabolic and genomic characteristics of patients with metabolic syndrome and/or diabetes that are at risk for developing complications differ from each other and can be detected using specific biomarkers in blood or in the exhaled breath. Early detection of these individuals will enable personalized treatment to prevent and treat diabetes and its complications
Breath samples will be collected in inert respiratory bag from diabetic and healthy volunteers, and analyzed using a chamber containing nano-chemical sensors. These samples together with blood samples will additionally be characterized using Gas Chromatography-Mass Spectroscopy "GC-MS".
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exhaled breath uptake blood test | Experimental | Diabetic patients receiving oral hypoglycemic drug will be tested for biomarkers in their breath and blood samples |
|
| Exhaled breath and blood test | No Intervention | Breath and blood samples will be collected from healthy volunteers and analyzed using Gas Chromatography-Mass Spectroscopy. The results will be compared to the experimental arm. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Breath analysis and blood analysis | Other | Exhaled breath and blood samples will be collected and further tested using Gas Chromatography-Mass Spectroscopy system. |
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| Measure | Description | Time Frame |
|---|---|---|
| Development of Diabetes or complication | 2 years |
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Inclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Eddy Karnieli, MD | Contact | +97248541606 | eddy@rambam.health.gov.il | |
| Margalit Levy, BA | Contact | +97248541606 | endo@rambam.health.gov.il |
| Name | Affiliation | Role |
|---|---|---|
| Eddy Karnieli, MD | Rambam Medicl Center, Technion | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rambam Medical Center - Inst. Endocrinology, Diabetes & Metabolism | Haifa | 31096 | Israel |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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|
| D009750 |
| Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |