Sleep Apnea Syndrome on Acromegaly: Impact of the Treatment on the Carbohydrates Metabolism.

Sleep Apnea Syndrome on Acromegaly: Impact of the Treatment on the Carbohydrates Metabolism.

Sleep apnea is a common situation that affects up to 80% of acromegalic patients. This disease is linked to disturbance on the carbohydrate metabolism increasing the rates of diabetes. The objective of this trial is to assess (with the euglycemic hyperinsulinemic clamp) the impact of the treatment of sleep apnea, with a continuous positive air pressure device (CPAP), on the insulin resistance.

Inclusion Criteria:

• Acromegalic patients
• Moderate to severe sleep apnea
• Using somatostatin analogues at maximum dosage possible for at least 6 month

Exclusion Criteria:

• Unstable angina or high risk for stroke
• Hepatic or renal insufficiency
• Uncontrolled diabetes
• Seizures
• Steroids use
• Uncontrolled hormonal deficiencies