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| Name | Class |
|---|---|
| US Department of Veterans Affairs | FED |
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This study will evaluate the effects of low-intensity strengthening exercise on the brain (thinking and processing speed) for patients with early dementia, compared with normative older adults. Participants will engage in 3 months of exercise 3-5 times per week using a chair and small weights. It is hypothesized that there will be a significant improvement in brain function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early stage dementia | Experimental | Individuals with early stage dementia who attended a Adult Day Care Program at least twice a week. Participants engaged in a strengthening exercise program three to five times per week for 10 weeks. |
|
| Normative older adults | Active Comparator | Normative older adults with no known neurological condition. Participants engaged in a strengthening exercise program three to five times per week for 10 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Strengthening exercise | Behavioral | 3 months of 3-5 times per week of low-intensity exercises using a chair and small weights |
|
| Measure | Description | Time Frame |
|---|---|---|
| Stroop Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Lower scores on Stroop C (possible range 0-240 sec) represents better performance). | Baseline and 3 months |
| Digits Backwards Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Digits backwards possible score range is 0-14 points). | Baseline and 3 months |
| Color Trails Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Color Trails possible score range is 0-300 seconds). | Baseline and 3 months |
| Fuld Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Fuld Semantic Recall possible score range is 0-20 points; Fuld Immediate and Delayed Recall possible score range is 0-10). | Baseline and 3 months |
| Figure Copy & Delayed Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Figure Copy & Delayed possible score range is 0-36 points). | Baseline and 3 months |
| Neurophysiological Function Pre- & Post- Intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cay Anderson-Hanley, PhD | Union College | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stratton VA Medical Center | Albany | New York | 12208 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22136405 | Result | Yerokhin V, Anderson-Hanley C, Hogan MJ, Dunnam M, Huber D, Osborne S, Shulan M. Neuropsychological and neurophysiological effects of strengthening exercise for early dementia: a pilot study. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2012;19(3):380-401. doi: 10.1080/13825585.2011.628378. Epub 2011 Dec 2. |
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Early stage dementia participants were drawn from the Adult Day Care Program (ADCP) at a Veterans Affairs Medical Center (VAMC) in the northeast United States. Normative older adult participants were either employees or volunteers at the same facility recruited by fliers.
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| ID | Title | Description |
|---|---|---|
| FG000 | Early Stage Dementia | Individuals with early stage dementia who attended a Adult Day Care Program at least twice a week. |
| FG001 | Normative Older Adults | Normative older adults with no known history of neurological condition. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
13 early dementia participants and 9 normative older adult participants.
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| ID | Title | Description |
|---|---|---|
| BG000 | Early Stage Dementia | Individuals with early stage dementia who attended a Adult Day Care Program at least twice a week. |
| BG001 | Normative Older Adults | Normative older adults with no known history of neurological condition. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Stroop Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Lower scores on Stroop C (possible range 0-240 sec) represents better performance). | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Posted | Mean | Standard Deviation | Time to complete (seconds) | Baseline and 3 months |
|
3 months
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Early Stage Dementia | Individuals with early stage dementia who attended a Adult Day Care Program at least twice a week. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Cay Anderson-Hanley, PhD | UNION COLLEGE | 518-388-6355 | andersoc@union.edu |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D003704 | Dementia |
| D000544 | Alzheimer Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
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|
Resting EEG and ERP recordings before (T1) and after (T2) strengthening exercise intervention
| Baseline and 3 months |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
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| Education | Mean | Full Range | years |
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| Normative Older Adults |
Normative older adults with no known history of neurological condition. |
|
|
| Primary | Digits Backwards Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Digits backwards possible score range is 0-14 points). | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Posted | Mean | Standard Deviation | Points | Baseline and 3 months |
|
|
|
| Primary | Color Trails Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Color Trails possible score range is 0-300 seconds). | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Posted | Mean | Standard Deviation | Time to complete (seconds) | Baseline and 3 months |
|
|
|
| Primary | Fuld Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Fuld Semantic Recall possible score range is 0-20 points; Fuld Immediate and Delayed Recall possible score range is 0-10). | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Posted | Mean | Standard Deviation | Points | Baseline and 3 months |
|
|
|
| Primary | Figure Copy & Delayed Test Performance From Pre- to Post-intervention | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Figure Copy & Delayed possible score range is 0-36 points). | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Posted | Mean | Standard Deviation | Points | Baseline and 3 months |
|
|
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| Primary | Neurophysiological Function Pre- & Post- Intervention | Resting EEG and ERP recordings before (T1) and after (T2) strengthening exercise intervention | Not Posted | Baseline and 3 months |
| 0 |
| 13 |
| 0 |
| 13 |
| EG001 | Normative Older Adults | Normative older adults with no known history of neurological condition. | 0 | 9 | 0 | 9 |
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| D002493 |
| Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D001519 | Behavior |
| Fuld Immediate Recall pre |
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| Fuld Immediate Recall post |
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| Fuld Delayed Recall pre |
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| Fuld Delayed Recall post |
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| Figure Delayed Recall pre |
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| Figure Delayed Recall post |
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