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| ID | Type | Description | Link |
|---|---|---|---|
| PHRC 2009/1910 | Other Grant/Funding Number | hospital clinical research program, French health ministry | |
| 2009-A00526-51 | Other Identifier | ID-RCB number, AFSSAPS |
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The primary purpose of the trial is to evaluate coagulation activator markers in patients with pre eclampsia compared to control (normal pregnancy) and to correlate these markers with the severity of the pathology.
100 pre-eclamptic patients will be compared to 200 control patients (100 control matched on gestational age at inclusion and 100 control matched on delivery mode (section).
Blood and urine samples will be collected at PE diagnosis, delivery and post partum.
Two axes will be considered:
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| Measure | Description | Time Frame |
|---|---|---|
| Endogenous thrombin potential | comparison of Endogenous thrombin potential between patients with Preclampsia (PE) (at the moment of the diagnosis of PE) compared to control (at the same gestational age) | at preeclampsia diagnosis |
| Measure | Description | Time Frame |
|---|---|---|
| genotype-phenotype correlation (Polymorphism of prostacyclin-synthetase promoter CYP8A1 | at pre eclampsia diagnosis | |
| In preeclampsia group : correlation between biological markers and severity of the disease | correlation of endogenous thrombin potential and rotem results with : presence or absence of severe preeclampsia presence or absence of HELLP Syndrome presence or absence of IUGR presence or absence of eclampsia |
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Inclusion Criteria:
Exclusion Criteria:
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pregnant women from two University hospitals in France
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| Name | Affiliation | Role |
|---|---|---|
| Véronique Houfflin Debarge, PHD | Universituy Hospital Of Lille, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Lille | Lille | Nord | 59037 | France |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| at the diagnosis of preeclampsia |
| evolution of endogenous thrombin potential in women with preeclampsia | Study of the evolution of endogenous thrombin potential during the time period of diagnosis of preeclampsia to day 2 of the post partum. | between the diagnosis of preeclampsia and day 2 of the post partum period |