Fractional CO2 Laser Assisted Photodynamic Therapy

Conventional Versus Fractional CO2 Laser Assisted Photodynamic Therapy for Basal Call Carcinomas and Actinic Keratoses

Nodular Basal Cell Carcinomas:

Compare the efficacy and safety of conventional versus fractional laser assisted PDT for difficult to treat nodular cell carcinomas in the face.

Actinic keratosis:

Compare the efficacy and safety of conventional versus fractional laser assisted PDT for moderate to severe actinic keratoses located in the face and on the hands.

Inclusion Criteria:

• Age 18 or older
• Skin type I-III
• Fertile women using secure birth control
• Moderate to severe actinic keratoses in the face or on the hands,
• Difficult to treat nodular basal cell carcinomas in the face

Exclusion Criteria:

• Pregnancy or breast feeding patients
• Patients with porphyria
• Patients with Gorlins syndrome
• Patients with a tendency to produce hypertrophic scars or keloids
• Patients with known allergy to Metvix
• Patients who are not considered able to follow the treatment protocol (e.g. severely alcoholic, dementia, mentally ill etc.)
• Patients with pigmented or morphea basal cell carcinomas
• Know herpes simplex virus infection in treatment areas