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| ID | Type | Description | Link |
|---|---|---|---|
| 2009-018169-12 | EudraCT Number |
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The primary objective is to determine whether, during a rapid sequence intubation by etomidate, and succinylcholine Sellick maneuver, the administration of remifentanil at 2 different dosages (0.5 and 1.0 microgram per kg body weight), reduces potentially dangerous reactional tachycardia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.5 µg / kg remifentanil | Experimental | Induction anesthesia includes 0.5 µg/kg remifentanil in addition to classic induction anesthesia protocol. |
|
| 1.0 µg/kg remifentanil | Experimental | Induction anesthesia includes 1.0 µg/kg remifentanil in addition to the classic induction protocol. |
|
| NaCl | Placebo Comparator | An equivalent volume (1 ml for 10 kg of weight) of isotonic 0.9% NaCl is injected in addition to the classic anesthesia induction protocol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0.5 µg/kg remifentanil | Drug | 0.5 µg/kg remifentanil is used during induction in addition to the classic induction protocol |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac frequency (beats per minute) | Patient cardiac frequency (beats per minute) at the time of induction | 15 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Arnaud Chaumeron, MD | Centre Hospitalier Universitaire de Nīmes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire de Nîmes | Nîmes | Gard | 30029 | France | ||
| Polyclinique Grand Sud |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31614244 | Result | Chaumeron A, Castanie J, Fortier LP, Basset P, Bastide S, Alonso S, Lefrant JY, Cuvillon P. Efficacy and safety of remifentanil in a rapid sequence induction in elderly patients: A three-arm parallel, double blind, randomised controlled trial. Anaesth Crit Care Pain Med. 2020 Apr;39(2):215-220. doi: 10.1016/j.accpm.2019.09.010. Epub 2019 Oct 12. |
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Data available upon request.
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| ID | Term |
|---|---|
| D013610 | Tachycardia |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D000075224 | Cardiac Conduction System Disease |
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| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| 1.0 µg/kg remifentanil | Drug | 1.0 µg/kg remifentanil is added to the classic induction anesthesia protocol |
|
| NaCl | Drug | an equivalent volume (1 ml for 10 kg of weight) of 0.9% isotonic NaCl is injected in addition to the classic anesthesia induction protocol |
|
| Nîmes |
| Gard |
| 30029 |
| France |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |