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To evaluate the effects of a high-calorie high-fat meal on the extent and rate of absorption of CHF 5074 after single oral administration in young healthy male volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CHF 5074 (fed group) | Experimental | oral tablet, single dose |
|
| CHF 5074 (fasting group) | Experimental | oral tablet, single dose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CHF 5074 | Drug | Drug is administered to subject in a fasting state |
| |
| Measure | Description | Time Frame |
|---|---|---|
| area under the curve of plasma CHF 5074 levels from 0 to 96 hours (AUC 0-96) | from Day 1 to Day 5 | |
| peak CHF 5074 plasma concentration (Cmax) | from Day 1 to Day 5 |
| Measure | Description | Time Frame |
|---|---|---|
| the time of occurrence of Cmax (Tmax) | from Day 1 to Day 5 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Magdy L. Shenouda, MD | Iberica Clinical Research Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Iberica Clinical Research Center | Eatontown | New Jersey | 07724 | United States |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| C522246 | 1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid |
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| CHF 5974 |
| Drug |
Drug is administered to subject after consumption of a high fat, high calorie meal |
|
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |