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This pilot study is using a novel technology to measure the rate of turnover of new fat cells. Analysis of volunteer samples is ongoing, however the study is currently not enrolling new volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy subjects | 18-49 year old healthy men and women. Free of significant chronic medical illness and illicit substance abuse. Body mass index from 20 to 27. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 15N-Thymidine, 2H-Water | Biological | Stable isotope 15N-thymidine, infused IV (15mg/hour) for 72 hours (phase 1 pilot). Stable isotope 2H-water, ingested by mouth once per day for 3 days (phase 1 pilot) or 28 days (phase 2 pilot). |
| Measure | Description | Time Frame |
|---|---|---|
| Quantifying human adipogenesis-counting the number of new fat cells. | 4 weeks-7 months |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy volunteers. Aged 18-49 years. Free of significant chronic medical illness. Free of illicit substance abuse.
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| Name | Affiliation | Role |
|---|---|---|
| Matthew L Steinhauser, MD | Brigham and Women's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22246326 | Result | Steinhauser ML, Bailey AP, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature. 2012 Jan 15;481(7382):516-9. doi: 10.1038/nature10734. |
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Fat biopsy. Oral mucosal smear. White blood cells.