Long-term Caloric Restriction and Cellular Aging Markers

Caloric Restriction With Optimal Nutrition and Aging Study

The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.

Inclusion Criteria:

• Calorie restricting group: Self-reported caloric restriction for at least two years
• Calorie restriction group: BMI below 23
• Normal eating control: Normal eating (no history of caloric restriction) for two years
• Normal eating control: BMI below 30
• Obese comparison group: BMI above 30
• Obese comparison group: Normal eating (no history of caloric restriction) for two years

Exclusion Criteria:

• Regular smoker for the past six months