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This study aims to test the effect of Doxycycline in treatment of uterine bleeding during the use of injectable contraception that contains one hormone "progesterone only".
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Women in this arm will receive identical Placebo capsules twice daily for 5 days |
|
| Doxycycline | Active Comparator | Women in this arm will receive 100 mg doxycycline capsules twice daily for 5 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Doxycycline | Drug | 100 mg Doxycycline capsules twice daily for 5 days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Stoppage of bleeding within 7 days | 7 days from starting of tretment |
| Measure | Description | Time Frame |
|---|---|---|
| Number of days needed to stop a current attack of bleeding | 1 month | |
| Next bleeding free interval | 3 month | |
| Uterine bleeding patterns in the next 3 months after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hany Abdel-Aleem, MD | Assiut University | Principal Investigator |
| Omar M Shaaban, MD | Assiut University | Study Director |
| Mahmoud Abdel=Aleem, MD | Assiut University | Study Chair |
| Gehian N Fetih, PH.D | Faculty of Pharmacy, Assiut University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine | Asyut | Asyut Governorate | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22325113 | Derived | Abdel-Aleem H, Shaaban OM, Abdel-Aleem MA, Fetih GN. Doxycycline in the treatment of bleeding with DMPA: a double-blinded randomized controlled trial. Contraception. 2012 Sep;86(3):224-30. doi: 10.1016/j.contraception.2012.01.003. Epub 2012 Feb 9. |
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| ID | Term |
|---|---|
| D014592 | Uterine Hemorrhage |
| ID | Term |
|---|---|
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D004318 | Doxycycline |
| ID | Term |
|---|---|
| D013754 | Tetracyclines |
| D009279 | Naphthacenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
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| Placebo |
| Drug |
Placebo capsules twice daily for 5 days |
|
| 3 months |
| Women satisfaction with the treatment she received | 3 months |
| Side effects encountered during treatment | 5 days |
| Discontinuation of the DMPA and its reason | 3 months |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006844 |
| Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D011083 | Polycyclic Compounds |