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| ID | Type | Description | Link |
|---|---|---|---|
| Study 3 |
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| Name | Class |
|---|---|
| Karolinska Institutet | OTHER |
| Swedish International Development Cooperation Agency (SIDA) | OTHER_GOV |
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The aim of the present study was to investigate the effects of Gynostemma Pentaphyllum tea on insulin sensitivity in drug-naïve type 2 diabetic patients.
In Vietnam, traditional herbal medicines have played a major role in the management of diabetes for centuries. Gynostemma Pentaphyllum (GP) Makino (Family Cucurbitaceae) is a perennial creeping herb growing wild in the mountainous regions of Vietnam, China and some other Asian countries and was widely used in Southeast Asian countries as an herbal medicine and being beneficial for the prevention and treatment of diabetes. We have previously published the evidences that GP tea possessed anti-diabetic effect with good safety data in newly diagnosed T2D patients, and had effect on insulin sensitivity. In addition extract of GP had been shown to reduce both hyperglycemia and hyperlipidemia in diabetic Zucker Fatty rats. So the present study was to investigate the effects of Gynostemma Pentaphyllum tea in insulin sensitivity in type 2 diabetic patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo tea | Placebo Comparator | Dietary Supplement: Placebo tea 3 gram twice daily, orally |
|
| Gynostemma pentaphyllum Tea | Active Comparator | Gynostemma Pentaphyllum tea 3 grams twice daily, orally |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gynostemma Pentaphyllum tea | Dietary Supplement | 6g/day per oral, twice a day in 10 weeks, 30 minutes before breakfast and dinner |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fating plasma glucose, Steady state plasma glucose in Somatostatin-Insulin-Glucose Infusion Test | All subjects participated in Somatostatin-Insulin-Glucose Infusion Test (SIGIT), lasting 150 minutes, performed at 8am after an 8-10h overnight fast with only tap water allowed ad libitum. Somatostatin was used to suppress endogenous insulin release, thereby allowing estimation of sensitivity to exogenously administered insulin by measuring blood glucose value at 90, 120 and 150 minute of the test (SIGIT mean). | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Liver enzymes (ALT, AST) | 10 weeks | |
| Kidney function (S-creatinine, S-BUN) | 10 weeks | |
| Plasma lipids (TG, Cholesterol, HDL-, LDL-) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Claes-Goran Ostenson, MD, Ph.D | Karolinska Institutet | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Institute of Gerontology, HMU | Hanoi | Vietnam | ||||
| National Institute of Gerontology |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20213586 | Background | Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010 May;42(5):353-7. doi: 10.1055/s-0030-1248298. Epub 2010 Mar 8. | |
| 17283239 | Background | Hoa NK, Norberg A, Sillard R, Van Phan D, Thuan ND, Dzung DT, Jornvall H, Ostenson CG. The possible mechanisms by which phanoside stimulates insulin secretion from rat islets. J Endocrinol. 2007 Feb;192(2):389-94. doi: 10.1677/joe.1.06948. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Placebo tea | Dietary Supplement | 6g/day per oral, twice a day in 10 weeks, 30 minutes before breakfast and dinner |
|
|
| 10 weeks |
| Blood pressure | 10 weeks |
| Body weight (BMI, hip-waist ratio) | 10 weeks |
| Hanoi |
| Vietnam |
| 19536359 | Background | Hoa NK, Phan DV, Thuan ND, Ostenson CG. Screening of the hypoglycemic effect of eight Vietnamese herbal drugs. Methods Find Exp Clin Pharmacol. 2009 Apr;31(3):165-9. doi: 10.1358/mf.2009.31.3.1362514. |
| 15220351 | Background | Norberg A, Hoa NK, Liepinsh E, Van Phan D, Thuan ND, Jornvall H, Sillard R, Ostenson CG. A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum. J Biol Chem. 2004 Oct 1;279(40):41361-7. doi: 10.1074/jbc.M403435200. Epub 2004 Jun 25. |
| D004700 | Endocrine System Diseases |
| D006946 | Hyperinsulinism |