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The study is to assess if sitaxsentan and ritonavir will affect the blood levels of each other when coadministered.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment A | Active Comparator |
| |
| Treatment B | Active Comparator |
| |
| Treatment C | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sitaxentan | Drug | Sitaxsentan Tablet, 100 mg, q24h (once daily) for 5 days. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The comparison of peak plasma concentration of sitaxsentan when coadministered with ritonavir versus sitaxsentan administered alone. | 24 hours | |
| The comparison of area under the curve of sitaxsentan when coadministered with ritonavir versus sitaxsentan administered alone. | 24 hours | |
| The comparison of peak plasma concentration of ritonavir when coadministered with sitaxsentan versus ritonavir administered alone. | 24 hours | |
| The comparison of area under the curve of ritonavir when coadministered with sitaxsentan versus ritonavir administered alone. | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
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| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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| ID | Term |
|---|---|
| D000081029 | Pulmonary Arterial Hypertension |
| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| C106276 | sitaxsentan |
| D019438 | Ritonavir |
| ID | Term |
|---|---|
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D001393 | Azoles |
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| Ritonavir |
| Drug |
Ritonavir Capsule, 100 mg, q12h (twice daily) for 5 days (morning dose only on Day 5). |
|
| Sitaxsentan | Drug | Sitaxsentan Tablet, 100 mg, q24h (once daily) for 5 days |
|
| Ritonavir | Drug | Ritonavir Capsule, 100 mg, q12h (twice daily) for 5 days |
|
| D006573 |
| Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |