Drug Interaction Between Ritonavir And Sitaxsentan

A Phase 1, Open Label, Randomized, Multiple Dose Study To Assess The Two-Way Drug Interaction Between Sitaxsentan And Low Dose Ritonavir In Healthy Subjects

The study is to assess if sitaxsentan and ritonavir will affect the blood levels of each other when coadministered.

Inclusion Criteria:

• Healthy male subjects and/or women of non-child bearing potential.
• Subjects (because of teratogenic risk of sitaxsentan) between the ages of 21 and 55 years, inclusive.
• Signed informed consent.

Exclusion Criteria:

• Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease.
• History of significant alcohol and drug use.
• Has hepatic dysfunction.