A Randomized Controlled Study to Assess the Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Subjects With Essential Hypertension

Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Patients With Essential Hypertension

This is a Phase 4, prospective, multi-centric and randomized controlled study to compare the effects of bisoprolol and atenolol on resting heart rate (RHR) and sympathetic nervous system's (SNS) activity in subjects with essential hypertension.

Inclusion Criteria:

• Subjects aged between 25-65 years
• Subjects with essential hypertension (EH)
• Subjects with systolic blood pressure (SBP) 140-160 millimeter of mercury (mmHg) and diastolic blood pressure (DBP) 90-100 mmHg
• Subjects with normal sinus rhythm
• Subjects with resting heart rate (RHR) greater than 70 bpm
• Subjects who give written informed consent

Exclusion Criteria:

• Subjects with atrial fibrillation (AF)/sick sinus syndrome (SSS)/atrioventricular block II-III Grade (AVB II-III) without pacemaker
• Subjects with bradyarrhythmia/hypotension
• Subjects with unstable angina pectoris (UAP)/acute myocardial infarction (AMI)/heart failure (HF) (New York Heart Association [NYHA] Class III - IV)
• Subjects with uncontrolled diabetes mellitus (DM)
• Subjects with bronchial asthma
• Subjects with gastro-intestinal ulcer or skin ulcer
• Subjects with liver dysfunction/renal impairment
• Subjects treated with calcium channel blockers (except amlodipine) or other beta-blockers.
• Subjects with glaucoma
• Subjects with known allergic/intolerance to beta-blocker
• Pregnant or lactating women
• Subjects who had participated in another clinical study within the last 3 months
• Subjects who have legal incapacity or limited legal capacity