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The 18F-FDOPA PET tracer is an amino acid analogue that can be used to visualize high-grade glioma not clearly identified on diagnostic MRI. Use of 18F-FDOPA PET will permit neurosurgeons to achieve a complete resection more frequently.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 18F-DOPA PET imaging | Experimental | Subjects will undergo preoperative 18F-FDOPA PET imaging, which will be used in neuronavigation software to guide resection of their high-grade glioma. Postoperative 18F-FDOPA PET imaging will be obtained to determine the extent of resection. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surgical neuronavigation with 18F-DOPA PET imaging | Procedure | Subjects will undergo preoperative 18F-FDOPA PET imaging, which will be used in neuronavigation software to guide resection of their high-grade glioma. Postoperative 18F-FDOPA PET imaging will be obtained to determine the extent of resection. |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of subjects that have a complete resection of the volume of 18F-FDOPA PET tracer on their postoperative 18F-FDOPA PET scan. | Less than 72 hours postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alan Nichol, MD | British Columbia Cancer Agency | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lions Gate Hospital | North Vancouver | British Columbia | V7L 2L7 | Canada | ||
| Vancouver General Hospital |
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| Label | URL |
|---|---|
| BC Cancer Agency | View source |
| UBC Department of Surgery | View source |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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|
| Vancouver |
| British Columbia |
| V5Z 1M9 |
| Canada |
| BC Cancer Agency | Vancouver | British Columbia | V5Z 4E6 | Canada |