This trial is a food-effect study to assess fasted versus fed pharmacokinetics of PL2200.

Inclusion Criteria:

• Healthy normal male and female volunteers between 21 and 65 years of age.

Exclusion Criteria:

• Abnormal findings on physical examination or clinical laboratories, or significant medical history.
• Subject with hypersensitivity or contraindications to aspirin, ibuprofen, or other nonsteroidal anti-inflammatory drug (NSAID).