The effective dosage of a n3-LC-PUFA intervention (with n3 LC-PUFA-enriched yoghurt) on the modulation of cardiovascular risk factors and inflammatory biomarkers were determined.

Fifty three mildly hypertriacylglycerolemic subjects (TAG ≥ 150 mg/dL (1.7 mmol/L)) participated on the placebo-controlled, double-blind, parallel designed study.

The subjects consumed placebo yoghurt (1), or n3 LC-PUFA-enriched yoghurt (0.8 g n3 LC-PUFA/d (2), 3 g n3 LC-PUFA/d (3)) for 10 weeks.

Blood samples were taken at the beginning and at the end of the period.

Parameters:

• Blood lipids (total cholesterol, HDL, LDL, triacylglycerols)
• Fatty acid distribution of plasma lipids (PL) and erythrocyte membranes (EM)
• Concentrations of eicosanoids (PGs, HETEs)
• Production of ex vivo stimulated cytokines by T cells
• SNPs in the CD36 genotype

Inclusion Criteria:

• hypertriacylglycerolemic subjects (TAG: ≥ 150 mg/dl (1.7 mmol/l))

Exclusion Criteria:

• patients receiving blood-diluting and lipid-lowering medications or glucocorticoids
• patients suffering from gastrointestinal or metabolic diseases (e.g., diabetes mellitus, hyper- and hypothyroidism) and hypercholesteremic patients with familial previous impacts
• patients taking dietary supplements (e.g., fish oil capsules, vitamin E) or having either known allergies or foodstuff indigestibility
• further exclusion criteria: smoking, high sportive activity or daily alcohol intake