The primary objective of this study is to assess the safety and efficacy of voclosporin as therapy in subjects with active noninfectious uveitis involving the intermediate and/or posterior segments of the eye (i.e., anterior + intermediate-, intermediate-, posterior- or pan-uveitis).

Inclusion Criteria:

• Active noninfectious uveitis involving the intermediate and/or posterior segment (i.e., anterior + intermediate-, intermediate-, posterior- or pan-uveitis) in at least one eye as evidenced by a vitreous haze grade of at least 2+ at the baseline visit. Subjects who also have anterior segment involvement need not be excluded if otherwise qualified.

• Subjects must be:

  • Capable of understanding the purpose and risks of the study.
  • Able to give written informed consent.
  • Able to comply with all study requirements.

Exclusion Criteria:

• Ocular Disease/Conditions

• The following conditions are exclusionary if present:

  • Uveitis limited to only the anterior segment of the study eye.
  • Confirmed or suspected infectious uveitis in either eye.

• Prior and Current Treatment:

  - As defined in the protocol

• Extraocular Conditions:

  - As defined in the protocol.

• Laboratory, Blood Pressure and ECG Evaluations:

  • As defined in the protocol.