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Difficulty of recruitment
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The main objective of this study is to evaluate the efficiency of the oxygen therapy delivery system Optiflow® compared to 2 others standard oxygen therapy delivery systems (Ospal®, non invasive ventilation).12 immunocompetent patients will compare the successive use of oxygen therapy delivery systems Optiflow®/Ospal® and 12 immunodeficient patients will compare the successive use of systems Optiflow®/Non invasive ventilation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VNI/Optiflow, Immunodeficient patients | Experimental | VNI = non invasive ventilation |
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| Optiflow/VNI, Immunodeficient patients | Experimental | VNI = non invasive ventilation |
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| Ospal/Optiflow, Immunocompetent patients | Experimental |
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| Optiflow/Ospal, Immunocompetent patients | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxygen therapy delivery systems | Other | T-60 (minutes) : clinical examination, blood gas, electrocardiogram; T0 / First oxygen therapy delivery system: clinical examination, blood gas, electrocardiogram, measurement of positive and expiratory pressure and FiO2; T10 : blood gas; Between T0 and T60 (every 10 minutes): clinical examination, measurement of positive and expiratory pressure and FiO2; T60 / Second oxygen therapy delivery system: clinical examination, blood gas, electrocardiogram, measurement of positive and expiratory pressure and FiO2; T70 : blood gas; Between T60 and T120 (every 10 minutes): clinical examination, measurement of positive and expiratory pressure and FiO2; T120: clinical examination, blood gas, electrocardiogram, measurement of positive and expiratory pressure and FiO2 |
| Measure | Description | Time Frame |
|---|---|---|
| Calcul of the ratio PaO2/FiO2 | The main objective of this study is to evaluate the efficiency of the oxygen therapy delivery system Optiflow® compared to 2 others standard oxygen therapy delivery systems (Ospal®, non invasive ventilation) by calculating the ratio PaO2/FiO2 | one hour after each system used |
| Measure | Description | Time Frame |
|---|---|---|
| number of participants with adverse events | The secondary outcomes are to understand the mechanisms of action of Optiflow system and to evaluate the tolerance of this system:
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Noëlle BRULE, Dr | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes University Hospital | Nantes | France |
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| measure of respiratory frequency and blood gas | The secondary outcomes are to understand the mechanisms of action of Optiflow system and to evaluate the tolerance of this system:
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| measure of positive and expiratory pressure | The secondary outcomes are to understand the mechanisms of action of Optiflow system and to evaluate the tolerance of this system:
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