RCT. Two substudies (clinical and experimental). Main objective of the trial is to examine if oxytocin, compared to placebo shows any additional effect on the therapy achievements (outcome) of patients with borderline personality disorder, who receive an in-patient standard psychotherapy (Dialectical-behavioral-therapy, Marsha Linehan (2006)).

Secondary objectives :

Investigate if oxytocin compared to placebo enhances social trust and emotion recognition in patients with borderline personality disorder. Comparison of the effects of Oxytocin on patients with BPD and major depression.

Inclusion Criteria:

• Gender: Both, male and female
• Minimum Age: 18 Years
• Maximum Age: 50 Years
• Borderline personality disorder or major depression (clinical control group)
• Mini Mental Status Test > 27 (capacity to consent)

Exclusion Criteria:

• chronic or acute somatic health problems
• Schizophrenia
• Bipolar affective disorder
• pregnancy
• breast feeding
• neurological disorder
• allergy to antidegradants