The primary objective of this study is to compare the effect of CT327 to placebo against experimental induced superficial, deep and hyperalgesic pain.

The secondary objectives are to elucidate the mechanisms of CT327 using experimental pain models.

Inclusion Criteria:

• Subjects must be able to understand the contents of the study, comply with the study and willing to sign informed consent
• Subjects must be free from clinically significant illness or disease as determined by their medical history, physical examination, laboratory and other tests
• All male subjects must take adequate contraceptive precautions during the course of the study and for 30 days after their participation in the study has ended

Exclusion Criteria:

• Participation in other clinical studies within 3 months before screening
• Scheduled for surgery, medical treatment or any hospital admission that would fall within the study
• Use of strong painkillers
• Use of any analgesic within 24 hours before start of study
• Use of a regular course of prescribed medication and/or herbal medicine
• The presence of lesions, significant scars, cuts, wounds, dermal abnormalities, tattoos or naevi in the test areas
• A past history of contact dermatitis, psoriasis or keloid
• Any clinically significant ECG abnormality at screening
• A history of drug or other allergy that contraindicates his participation.
• Regular or average consumption of more than 21 units of alcohol per week (one unit of alcohol equals approximately 250 mL of beer, 125 mL of wine or 20 mL of spirits).
• Smokes more than five cigarettes (on average) per day, or had been a smoker of more than 5 cigarettes (on average) per day within the 3 months prior to screening.
• A known history of drug or alcohol abuse.
• As a result of the medical screening process, the PI or medical delegate considers the subject unfit for the study.
• Use of any prescription medication within 2 weeks or 5 half-lives (whichever is longer) of dosing.
• Use of non-prescription medication (e.g. aspirin, vitamins and herbal and dietary supplements) within 7 days prior to dosing, or 14 days if the medication contained grapefruit/ grapefruit juice or St John's Wort.