The current trial shall clarify the potential of the multitarget antiangiogenic tyrosinkinase inhibitor GW 786034 (pazopanib) in combination with oral cyclophosphamide as salvage treatment in patients with recurrent, pretreated ovarian cancer.

This study is a prospective open-label, non-randomized multicenter phase I/II trial in order to determine overall response rate of patients with platinum-resistant or refractory recurrent, pretreated epithelial ovarian cancer.

In order to assure adequate toxicity assessment, a phase-I-trial is proponed. Phase II will be performed with MTD.

Inclusion Criteria:

1. Written informed consent
2. Female subjects ≥18 years of age
3. Histologically or cytologically confirmed diagnosis of: epithelial ovarian cancer which is platinum resistant or platinum refractory,cancer of the fallopian tube, peritoneal cancer
4. Patients must have failed available standard chemotherapy regimen
5. Prior treatment with at least 2 chemotherapy regimens in advanced tumor setting
6. Performance status ECOG 0 - 2
7. Adequate contraception
8. Adequate organ function
9. Measurable disease according to RECIST criteria.
10. Able to swallow and retain oral medication.
11. Life expectancy of at least 12 weeks.

Exclusion Criteria:

1. Any second malignancy within the last 5 years, with the exception of basal cell or squamous cell skin cancer or in situ carcinoma of the cervix uteri

2. History or clinical evidence of central nervous system (CNS) metastases or leptomeningeal carcinomatosis, except for individuals who have previously-treated CNS metastases, are asymptomatic, and have had no requirement for steroids or anti-seizure medication for 6 months prior to first dose of study drug.

3. Clinically significant gastrointestinal abnormalities which might interfere with oral dosing

4. Any unstable or serious concurrent condition (e.g., active infection requiring systemic therapy).

5. Prolongation of corrected QT interval (QTc) >480 msecs.

6. History of any one or more of the following cardiovascular conditions within the past 6 months:

   • Cardiac angioplasty or stenting
   • Myocardial infarction
   • Unstable angina
   • Symptomatic peripheral vascular disease
   • Coronary artery by-pass graft surgery
   • Class II, III or IV congestive heart failure as defined by the New York Heart Association (NYHA)
   • History of cerebrovascular accident, pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6 months

7. Macroscopic hematuria

8. Hemoptysis that is clinically relevant within 4 weeks of first dose of study drug

9. Evidence of active bleeding or bleeding diathesis

10. Known endobronchial lesions or involvement of large pulmonary vessels by tumor

11. Prior major surgery or trauma within 14 days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer.

12. Chemotherapy or radiation therapy within 2 weeks prior to the first dose of study drug.

13. Biological therapy, hormonal therapy or treatment with an investigational agent within 28 days or 5 half-lives

14. Prior antiangiogenic therapy.

15. Is unable or unwilling to discontinue predefined prohibited medications listed in the protocol for 14 days or five half-lives of a drug (whichever is longer) prior to Visit 1 and for the duration of the study

16. Any ongoing toxicity from prior anti-cancer therapy that is > Grade 1 and/or that is progressing in severity.

17. Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib

18. Psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol.

19. Pregnancy

20. More than 3 different chemotherapy regimens in advanced tumor setting

21. Uncontrolled hypertension

22. History of ischemic event (stroke, myocardial infarction, unstable angina, TIA, symptomatic peripheral vascular disease)

23. History or clinical evidence of thrombo-embolic event

24. History of haemoptysis, cerebral, or clinically significant gastrointestinal haemorrhage in the past 6 months

25. Active bleeding

26. Signs/Suspicion of intestinal obstruction