Effect of a Low Glycemic Index Diet on Breast Density

Pilot Study of the Effect of a Low Glycemic Index Diet on Breast Density (Diet and Breast Health Study )

This study is a Pilot Phase II cancer intervention trial of a low glycemic index diet to reduce mammographic density in women at high risk for breast cancer.

Inclusion Criteria:

• Are between 40 and 60 years of age
• Still menstruating with at least 10 menstrual cycles in the previous 12 months
• Not Taking hormone replacement therapy
• Stable oral contraceptive use (no changes is use in past 12 months nor changes intended during interventional period)
• Have not been previously diagnosed with breast cancer, DCIS,lobular carcinoma in situ, atypical lobular hyperplasia or atypical hyperplasia
• No history of breast augmentation or reduction surgery
• Have no history of any other malignancy (excluding non-melanoma skin cancer) in the previous 5 years
• Have no history of diabetes or other metabolic diseases requiring dietary modification
• Have a study baseline mammographic density of at least 50% as estimated by mammographer
• BIRADS 1 or 2 mammogram if first ever mammogram, otherwise stable mammogram (no change since previous year)
• Have not followed a weight reduction or Atkins typs diet in the past 6 months Not pregnant or lactating in the past 12 months, nor intending pregnancy during the study period
• Successful completion of three baseline telephone-administered 24- hour dietary recalls